# Commission Regulation (EU) No 283/2013 of 1 March 2013 setting out the data requirements for active substances, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market (Text with EEA relevance), Division: Test conditions

Extent: E+W+S+N.I.

Studies shall be carried out in lactating goats, where available, or in lactating cows as an alternative.
Dose rates shall at least be equivalent to the likely maximum daily exposure resulting from all intended uses.
If the identification of main metabolites cannot be carried out with dose rates of 10 mg/kg feed (dry matter), higher doses may be used.
If no feeding studies are carried out, plateau levels in milk shall be demonstrated in the metabolism study taking into account that plateau levels usually occur five to seven days after the beginning of dosing in lactating ruminants.

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Source: https://www.legislation.gov.uk/eur/2013/283/annex/section/6/division/6.2/division/6.2.3/division/2 (the official version)
Page: https://openlegislation.uk/eu-regulation-2013-283/annex/section-6/division-6.2/division-6.2.3/division-2
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.