Paragraph 10 Biological test systems

Taking account of the relevant aspects referred to above relating to care, housing or containment of biological test systems, the inspector should check that—

• test systems are as specified in study plans,

• test systems are adequately identified,

• animals are adequately and, if necessary and appropriate, uniquely identified throughout the study,

• housing or containers of test systems are properly identified with all the necessary information,

• there is an adequate separation of studies being conducted on the same animal species (or the same biological test system) but with different substances,

• the biological test system environment is as specified in the study plan or in standard operating procedures for aspects such as temperature or light/dark cycles,

• the recording of the receipt, handling, housing or containment, care and health evaluation is appropriate to the test systems,

• written records are kept of examination, quarantine, morbidity, behaviour, diagnosis and treatment of animal and plant test systems or other similar aspects as appropriate to each biological test system,

• there are provisions for the appropriate disposal of test systems at the end of tests.