# The Human Medicines Regulations 2012, Paragraph 14R


The licence holder must submit to the licensing authority, at annual intervals, an update of any changes to the POC master file made in the previous 12 month period, the first update being required to be submitted no later than the date that is 12 months from the date on which the manufacturer’s licence (POC) was granted.

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Source: https://www.legislation.gov.uk/uksi/2012/1916/schedule/4/paragraph/14R (the official version)
Page: https://openlegislation.uk/human-medicines-regulations-2012/schedule-4/paragraph-14R
Contains public sector information licensed under the Open Government Licence v3.0. Source: legislation.gov.uk, The National Archives.