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Chapter 3.3. CALCULATION EXAMPLE FOR RUGGEDNESS TESTING OF MINOR CHANGES ACCORDING TO THE YOUDEN APPROACH (16)

United Kingdom

Original text. Later amendments are not shown.

Comparison of averages (A)

AA = Σ(Ai)/4

Compare the averages of the capital letters (AA to AG) with the averages of their corresponding small letters (Aa to Ag). If a factor have an effect, the difference will be significant larger than the differences of the other factors.

A robust method should not be affected by changes encountered almost certainly between laboratories.

If there is no outstanding difference, the most realistic measure of the random error is given by the seven differences.

AB = Σ(Bi)/4
AC = Σ(Ci)/4
AD = Σ(Di)/4
AE = Σ(Ei)/4
AF = Σ(Ei)/4
AG = Σ(Gi)/4
Aa = Σ(ai)/4
Ab = Σ(bi)/4
Ac = Σ(ci)/4
Ad = Σ(di)/4
Ae = Σ(ei)/4
Af = Σ(fi)/4
Ag = Σ(gi)/4
Differences (Di)Squares of differences (Di2)
Da = A – a = Σ(Ai) – Σ(ai)Da2 = value a
Db = B – b = Σ(Bi) – Σ(bi)Db2 = value b
Dc = C – c = Σ(Ci) – Σ(ci)Dc2 = value c
Dd = D – d = Σ(Di) – Σ(di)Dd2 = value d
De = E – e = Σ(Ei) – Σ(ei)De2 = value e
Df = F – f = Σ(Fi) – Σ(fi)Df2 = value f
Dg = G – g = Σ(Gi) – Σ(gi)Dg2 = value g
  1. Standard deviation of the differences Di (SDi):

Notes on Annex I

Textual amendments

F1

Replaced by virtue of 2003/181/EC: Commission Decision of 13 March 2003 amending Decision 2002/657/EC as regards the setting of minimum required performance limits (MRPLs) for certain residues in food of animal origin (Text with EEA relevance) (notified under document number C(2003) 764)