Division Laboratory criteria for case confirmation:
United Kingdom
At least one of the following five:
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TBE specific IgM AND IgG antibodies in blood
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TBE specific IgM antibodies in CSF
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Seroconversion or four-fold increase of TBE-specific antibodies in paired serum samples
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Detection of TBE viral nucleic acid in a clinical specimen,
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Isolation of TBE virus from clinical specimen
Notes on Division
Footnotes
- f1
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Serological results should be interpreted according to the vaccination status and previous exposure to other flaviviral infections. Confirmed cases in such situations should be validated by serum neutralization assay or other equivalent assays.