Division 3.1 Test report

The test report must include the following information, as appropriate:

Test substance:

• physical nature, purity, and, where relevant, physico-chemical properties (including isomerisation);

• identification data, including CAS number.

Vehicle (if appropriate):

• justification for choice of vehicle, if other than water.

Test animals:

• species/strain used;

• microbiological status of the animals, when known;

• number, age, and sex of animals (including, where appropriate, a rationale for the use of males instead of females);

• source, housing conditions, diet etc.;

Test conditions:

• details of test substance formulation including details of the physical form of the material administered;

• details of the administration of the test substance including dosing volumes and time of dosing;

• details of food and water quality (including diet type/source, water source);

• the rationale for the selection of the starting dose.

Results:

• tabulation of response data and dose level for each animal (i.e. animals showing signs of toxicity including mortality; nature, severity, and duration of effects);

• tabulation of body weight and body weight changes;

  individual weights of animals at the day of dosing, in weekly intervals thereafter, and at the time of death or sacrifice

• date and time of death if prior to scheduled sacrifice

• time course of onset of signs of toxicity, and whether these were reversible for each animal;

• necropsy findings and histopathological findings for each animal, if available.

Discussion and interpretation of results.

Conclusions.