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Division 2.2.1.3 The mode of action of the micro-organism should be evaluated in as much detail as appropriate. The possible role of metabolites/toxins for the mode of action should be evaluated and when identified, the minimal effective concentration for each active metabolite/toxin should be established. Information on mode of action can be a very valuable tool in identifying potential risks. Aspects to be considered in the evaluation, are:

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  1. (a)

    antibiosis,

  2. (b)

    induction of plant resistance,

  3. (c)

    interference with the virulence of a pathogenic target organism,

  4. (d)

    endophytic growth,

  5. (e)

    root colonisation,

  6. (f)

    competition of ecological niche (e.g. nutrients, habitats),

  7. (g)

    parasitisation,

  8. (h)

    invertebrate pathogenicity.