Division 2.8.2.2 A plant protection product may give rise to toxic effects due to the action of toxins or co-formulants. For the assessment of such effects the following information should be taken into consideration:

1. (a)

   studies on toxicity to aquatic organisms,

2. (b)

   information on fate and behaviour in the various parts of the environment.

If mortality or signs of intoxication are observed in the tests the evaluation must include a calculation of toxicity/exposure ratios based on the quotient of the EC₅₀ value and/or the NOEC value and the estimated exposure.