Division 2.8.4.2 A plant protection product may give rise to toxic effects due to the action of toxins or co-formulants. For the assessment of such effects the following information should be taken into consideration:

1. (a)

   studies on toxicity to arthropods,

2. (b)

   information on fate and behaviour in the various parts of the environment,

3. (c)

   available data from biological primary screening.

If mortality or signs of intoxication are observed in the tests the evaluation must include a calculation of toxicity/exposure ratios based on the quotient of the ER₅₀ value (effective rate) and the estimated exposure.