Division 5.2.4 An estimation of the exposure levels shall be performed for all human populations (workers, consumers and humans liable to exposure indirectly via the environment) and environmental spheres for which exposure to the substance is known or reasonably foreseeable. Each relevant route of human exposure (inhalation, oral, dermal and combined through all relevant routes and sources of exposure) shall be addressed. Such estimations shall take account of spatial and temporal variations in the exposure pattern. In particular, the exposure estimation shall take account of:X1

adequately measured, representative exposure data,

any major impurities and additives in the substance,

the quantity in which the substance is produced and/or imported,

the quantity for each identified use,

implemented or recommended risk management, including the degree of containment,

duration and frequency of exposure according to the operational conditions,

the activities of workers related to the processes and the duration and frequency of their exposure to the substance,

the activities of consumers and the duration and frequency of their exposure to the substance,

the duration and frequency of emissions of the substance to the different environmental compartments and the dilution in the receiving environmental compartment,

the physicochemical properties of the substance,

transformation and/or degradation products,

the likely routes of exposure of and potential for absorption in humans,

the likely pathways to the environment and environmental distribution and degradation and/or transformation (see also Section 3 Step 1),

scale (geographical) of exposure,

matrix dependent release/migration of the substance.