Division 3.5.1.2 F1

A mutation means a permanent change in the amount or structure of the genetic material in a cell. The term ‘ mutation ’ applies both to heritable genetic changes that may be manifested at the phenotypic level and to the underlying DNA modifications when known (including specific base pair changes and chromosomal translocations). The term ‘ mutagenic ’ and ‘ mutagen ’ will be used for agents giving rise to an increased occurrence of mutations in populations of cells and/or organisms.