Division Aim of the testF1

These studies are of value in:

• the prediction of genotoxic potential

• the early identification of genotoxic carcinogens

• the elucidation of the mechanism of action of some carcinogens.

To avoid responses that are artefacts of the test system, excessively toxic doses must not be used in either in vitro or in vivo assays for mutagenicity. This approach shall be regarded as general guidance. It is important that a flexible approach is adopted, with selection of further tests which are dependent upon interpretation of results at each stage.