Division 5.3 High accuracy (trueness and precision, bioassay apparent recovery)

For GC-MS methods, the determination shall provide a valid estimate of the true concentration in a sample. High accuracy (accuracy of the measurement: the closeness of the agreement between the result of a measurement with the true or assigned value of the measurand) is necessary to avoid the rejection of a sample analysis result on the basis of poor reliability of the determined TEQ level. Accuracy is expressed as trueness (difference between the mean value measured for an analyte in a certified material and its certified value, expressed as percentage of this value) and precision (RSD_R relative standard deviation calculated from results generated under reproducibility conditions).

For bioanalytical methods, the bioassay apparent recovery shall be determined.