Paragraph 5
The licence holder must inform the licensing authority of any change that the licence holder proposes to make to a person named in the licence as—
(a)
the person whose duty it is to supervise the manufacturing or assembling operations;
(b)
in charge of the animals from which are derived substances used in the production of the medicinal products being manufactured or assembled; or
(c)
responsible for the culture of living tissues used in the manufacture of the medicinal products being manufactured or assembled.