Division VIRUSES (*)F1
United Kingdom
(*) See paragraph 7 of the introductory notes.
| See paragraph 7 of the introductory notes. | ||
| Classification according to WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use. | ||
| See paragraph 8 of the introductory notes. | ||
| Tick-borne encephalitis. | ||
| Hepatitis delta virus is pathogenic in workers only in the presence of simultaneous or secondary infection caused by hepatitis B virus. Vaccination against hepatitis B virus will therefore protect workers who are not affected by hepatitis B virus against hepatitis delta virus. | ||
| Only for types A and B. | ||
| Recommended for work involving direct contact with these agents. | ||
| Two viruses are identified: one a buffalopox type and the other a variant of the Vaccinia virus. | ||
| Variant of cowpox virus. | ||
| Variant of Vaccinia. | ||
| At present there is no evidence of disease in humans caused by the other retroviruses of simian origin. As a precaution containment level 3 is recommended for work with them. | ||
| F2In line with Article 16(1)(c), non-propagative diagnostic laboratory work involving SARS-CoV-2 should be conducted at a facility using procedures equivalent to at least containment level 2. Propagative work involving SARS-CoV-2 should be conducted at a containment level 3 laboratory with air pressure negative to atmosphere. | ||
| Biological agent (virus species or indicated taxonomy order) | Classification | Notes |
|---|---|---|
| Bunyavirales (O) | ||
| Hantaviridae (F) | ||
| Orthohantavirus (G) | ||
| Andes orthohantavirus (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS]) | 3 | |
| Bayou orthohantavirus | 3 | |
| Black Creek Canal orthohantavirus | 3 | |
| Cano Delgadito orthohantavirus | 3 | |
| Choclo orthohantavirus | 3 | |
| Dobrava-Belgrade orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS]) | 3 | |
| El Moro Canyon orthohantavirus | 3 | |
| Hantaan orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS]) | 3 | |
| Laguna Negra orthohantavirus | 3 | |
| Prospect Hill orthohantavirus | 2 | |
| Puumala orthohantavirus (Hantavirus species causing Nephropathia Epidemica [NE]) | 2 | |
| Seoul orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS]) | 3 | |
| Sin Nombre orthohantavirus (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS]) | 3 | |
| Other hantaviruses known to be pathogenic | 2 | |
| Nairoviridae (F) | ||
| Orthonairovirus (G) | ||
| Crimean-Congo haemorrhagic fever orthonairovirus | 4 | |
| Dugbe orthonairovirus | 2 | |
| Hazara orthonairovirus | 2 | |
| Nairobi sheep disease orthonairovirus | 2 | |
| Other nairoviruses known to be pathogenic | 2 | |
| Peribunyaviridae (F) | ||
| Orthobunyavirus (G) | ||
| Bunyamwera orthobunyavirus (Germiston virus) | 2 | |
| California encephalitis orthobunyavirus | 2 | |
| Oropouche orthobunyavirus | 3 | |
| Other orthobunyaviruses known to be pathogenic | 2 | |
| Phenuiviridae (F) | ||
| Phlebovirus (G) | ||
| Bhanja phlebovirus | 2 | |
| Punta Toro phlebovirus | 2 | |
| Rift Valley fever phlebovirus | 3 | |
| Sandfly fever Naples phlebovirus (Toscana Virus) | 2 | |
| SFTS phlebovirus (Severe Fever with Thrombocytopenia Syndrome-Virus) | 3 | |
| Other phleboviruses known to be pathogenic | 2 | |
| Herpesvirales (O) | ||
| Herpesviridae (F) | ||
| Cytomegalovirus (G) | ||
| Human betaherpesvirus 5 (Cytomegalovirus) | 2 | |
| Lymphocryptovirus (G) | ||
| Human gammaherpesvirus 4 (Epstein-Barr virus) | 2 | |
| Rhadinoovirus (G) | ||
| Human gammaherpesvirus 8 | 2 | D |
| Roseolovirus (G) | ||
| Human betaherpesvirus 6A (Human B-lymphotropic virus) | 2 | |
| Human betaherpesvirus 6B | 2 | |
| Human betaherpesvirus 7 | 2 | |
| Simplexvirus (G) | ||
| Macacine alphaherpesvirus 1 (Herpesvirus simiae, Herpes B virus) | 3 | |
| Human alphaherpesvirus 1 (Human herpesvirus 1, Herpes simplex virus type 1) | 2 | |
| Human alphaherpesvirus 2 (Human herpesvirus 2, Herpes simplex virus type 2) | 2 | |
| Varicellovirus (G) | ||
| Human alphaherpesvirus 3 (Herpesvirus varicella-zoster) | 2 | V |
| Mononegavirales (O) | ||
| Filoviridae (F) | ||
| Ebolavirus (G) | 4 | |
| Marburgvirus (G) | ||
| Marburg marburgvirus | 4 | |
| Paramyxoviridae (F) | ||
| Avulavirus (G) | ||
| Newcastle disease virus | 2 | |
| Henipavirus (G) | ||
| Hendra henipavirus | 4 | |
| Nipah henipavirus | 4 | |
| Morbillivirus (G) | ||
| Measles morbillivirus | 2 | V |
| Respirovirus (G) | ||
| Human respirovirus 1 (Parainfluenza virus 1) | 2 | |
| Human respirovirus 3 (Parainfluenza virus 3) | 2 | |
| Rubulavirus (G) | ||
| Mumps rubulavirus | 2 | V |
| Human rubulavirus 2 (Parainfluenza virus 2) | 2 | |
| Human rubulavirus 4 (Parainfluenza virus 4) | 2 | |
| Pneumoviridae (F) | ||
| Metapneumovirus (G) | ||
| Orthopneumovirus (G) | ||
| Human orthopneumovirus (Respiratory syncytial virus) | 2 | |
| Rhabdoviridae (F) | ||
| Lyssavirus (G) | ||
| Australian bat lyssavirus | 3 f1 | V |
| Duvenhage lyssavirus | 3 | V |
| European bat lyssavirus 1 | 3 | V |
| European bat lyssavirus 2 | 3 | V |
| Lagos bat lyssavirus | 3 | |
| Mokola lyssavirus | 3 | |
| Rabies lyssavirus | 3 | V |
| Vesiculovirus (G) | ||
| Vesicular stomatitis virus, Alagoas vesiculovirus | 2 | |
| Vesicular stomatitis virus, Indiana vesiculovirus | 2 | |
| Vesicular stomatitis virus, New Jersey vesiculovirus | 2 | |
| Piry vesiculovirus (Piry virus) | 2 | |
| Nidovirales (O) | ||
| Coronaviridae (F) | ||
| Betacoronavirus (G) | ||
| Severe acute respiratory syndrome-related coronavirus (SARS-virus) | 3 | |
| Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) f2 | 3 | |
| Middle East respiratory syndrome coronavirus (MERS-virus) | 3 | |
| Other Coronaviridae known to be pathogenic | 2 | |
| Picornavirales (O) | ||
| Picornaviridae (F) | ||
| Cardiovirus (G) | ||
| Saffold virus | 2 | |
| Cosavirus (G) | ||
| Cosavirus A | 2 | |
| Enterovirus (G) | ||
| Enterovirus A | 2 | |
| Enterovirus B | 2 | |
| Enterovirus C | 2 | |
| Enterovirus D, Human Enterovirus type 70 (Acute haemorrhagic conjunctivitis virus) | 2 | |
| Rhinoviruses | 2 | |
| Poliovirus, type 1 and 3 | 2 | V |
| Poliovirus, type 2 f3 | 3 | V |
| Hepatovirus (G) | ||
| Hepatovirus A (Hepatitis A virus, Human Enterovirus type 72) | 2 | V |
| Kobuvirus (G) | ||
| Aichivirus A (Aichi virus 1) | 2 | |
| Parechovirus (G) | ||
| Parechoviruses A | 2 | |
| Parechoviruses B (Ljungan virus) | 2 | |
| Other Picornaviridae known to be pathogenic | 2 | |
| Unassigned (O) | ||
| Adenoviridae (F) | 2 | |
| Astroviridae (F) | 2 | |
| Arenaviridae (F) | ||
| Mammarenavirus (G) | ||
| Brazilian mammarenavirus | 4 | |
| Chapare mammarenavirus | 4 | |
| Flexal mammarenavirus | 3 | |
| Guanarito mammarenavirus | 4 | |
| Junín mammarenavirus | 4 | |
| Lassa mammarenavirus | 4 | |
| Lujo mammarenavirus | 4 | |
| Lymphocytic choriomeningitis mammarenavirus, neurotropic strains | 2 | |
| Lymphocytic choriomeningitis mammarenavirus (other strains) | 2 | |
| Machupo mammarenavirus | 4 | |
| Mobala mammarenavirus | 2 | |
| Mopeia mammarenavirus | 2 | |
| Tacaribe mammarenavirus | 2 | |
| Whitewater Arroyo mammarenavirus | 3 | |
| Caliciviridae (F) | ||
| Norovirus (G) | ||
| Norovirus (Norwalk virus) | 2 | |
| Other Caliciviridae known to be pathogenic | 2 | |
| Hepadnaviridae (F) | ||
| Orthohepadnavirus (G) | ||
| Hepatitis B virus | 3 | V, D |
| Hepeviridae (F) | ||
| Orthohepevirus (G) | ||
| Orthohepevirus A (Hepatitis E virus) | 2 | |
| Flaviviridae (F) | ||
| Flavivirus (G) | ||
| Dengue virus | 3 | |
| Japanese encephalitis virus | 3 | V |
| Kyasanur Forest disease virus | 3 | V |
| Louping ill virus | 3 | |
| Murray Valley encephalitis virus (Australia encephalitis virus) | 3 | |
| Omsk haemorrhagic fever virus | 3 | |
| Powassan virus | 3 | |
| Rocio virus | 3 | |
| St. Louis encephalitis virus | 3 | |
| Tick-borne encephalitis virus | ||
| Absettarov virus | 3 | |
| Hanzalova virus | 3 | |
| Hypr virus | 3 | |
| Kumlinge virus | 3 | |
| Negishi virus | 3 | |
| Russian spring-summer encephalitis f4 | 3 | V |
| Tick-borne encephalitis virus Central European subtype | 3 | V |
| Tick-borne encephalitis virus Far Eastern Subtype | 3 | |
| Tick-borne encephalitis virus Siberian subtype | 3 | V |
| Wesselsbron virus | 3 | |
| West Nile fever virus | 3 | |
| Yellow fever virus | 3 | V |
| Zika virus | 2 | |
| Other flaviviruses known to be pathogenic | 2 | |
| Hepacivirus (G) | ||
| Hepacivirus C (Hepatitis C virus) | 3 | D |
| Orthomyxoviridae (F) | ||
| Gammainfluenzavirus (G) | ||
| Influenza C virus | 2 | V f5 |
| Influenzavirus A (G) | ||
| Highly Pathogenic Avian Influenza Viruses HPAIV (H5), e.g. H5N1 | 3 | |
| Highly Pathogenic Avian Influenza Viruses HPAIV (H7), e.g. H7N7, H7N9 | 3 | |
| Influenza A virus | 2 | V |
| Influenza A virus A/New York/1/18 (H1N1) (Spanish flu 1918) | 3 | |
| Influenza A virus A/Singapore/1/57 (H2N2) | 3 | |
| Low Pathogenic Avian Influenza Virus (LPAI) H7N9 | 3 | |
| Influenzavirus B (G) | ||
| Influenza B virus | 2 | V |
| Thogoto virus (G) | ||
| Dhori virus (Tick-borne orthomyxoviridae : Dhori) | 2 | |
| Thogoto virus (Tick-borne orthomyxoviridae : Thogoto) | 2 | |
| Papillomaviridae (F) | 2 | D f6 |
| Parvoviridae (F) | ||
| Erythroparvovirus (G) | ||
| Primate erythroparvovirus 1 (Human parvovirus, B 19 virus) | 2 | |
| Polyomaviridae (F) | ||
| Betapolyomavirus (G) | ||
| Human polyomavirus 1 (BK virus) | 2 | D |
| Human polyomavirus 2 (JC virus) | 2 | D |
| Poxviridae (F) | ||
| Molluscipoxvirus (G) | ||
| Molluscum contagiosum virus | 2 | |
| Orthopoxvirus (G) | ||
| Cowpox virus | 2 | |
| Monkeypox virus | 3 | V |
| Vaccinia virus (incl. Buffalopox virus f7 , Elephantpox virus f8 , Rabbitpox virus f9 ) | 2 | |
| Variola (major and minor) virus | 4 | V |
| Parapoxvirus (G) | ||
| Orf virus | 2 | |
| Pseudocowpox virus (Milkers’ node virus, parapoxvirus bovis) | 2 | |
| Yatapoxvirus (G) | ||
| Tanapox virus | 2 | |
| Yaba monkey tumor virus | 2 | |
| Reoviridae (F) | ||
| Seadornavirus (G) | ||
| Banna virus | 2 | |
| Coltivirus (G) | 2 | |
| Rotavirus es (G) | 2 | |
| Orbivirus (G) | 2 | |
| Retroviridae (F) | ||
| Deltaretrovirus (G) | ||
| Primate T-lymphotropic virus 1 (Human T-cell lymphotropic virus, type 1) | 3 | D |
| Primate T-lymphotropic virus 2 (Human T-cell lymphotropic virus, type 2) | 3 | D |
| Lentivirus (G) | ||
| Human immunodeficiency virus 1 | 3 | D |
| Human immunodeficiency virus 2 | 3 | D |
| Simian Immunodeficiency Virus (SIV) f10 | 2 | |
| Togaviridae (F) | ||
| Alphavirus (G) | ||
| Cabassouvirus | 3 | |
| Eastern equine encephalomyelitis virus | 3 | V |
| Bebaru virus | 2 | |
| Chikungunya virus | 3 | |
| Everglades virus | 3 | |
| Mayaro virus | 3 | |
| Mucambo virus | 3 | |
| Ndumu virus | 3 | |
| O’nyong-nyong virus | 2 | |
| Ross River virus | 2 | |
| Semliki Forest virus | 2 | |
| Sindbis virus | 2 | |
| Tonate virus | 3 | |
| Venezuelan equine encephalomyelitis virus | 3 | V |
| Western equine encephalomyelitis virus | 3 | V |
| Other alphaviruses known to be pathogenic | 2 | |
| Rubivirus (G) | ||
| Rubella virus | 2 | V |
| Unassigned (F) | ||
| Deltavirus (G) | ||
| Hepatitis delta virus f11 | 2 | V, D |
Annotations
Textual amendments
- F1
- F2
Footnotes
- f1
-
See paragraph 8 of the introductory notes.
- f2
-
In line with Article 16(1)(c), non-propagative diagnostic laboratory work involving SARS-CoV-2 should be conducted at a facility using procedures equivalent to at least containment level 2. Propagative work involving SARS-CoV-2 should be conducted at a containment level 3 laboratory with air pressure negative to atmosphere.
- f3
-
Classification according to WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use.
- f4
-
Tick-borne encephalitis.
- f5
-
Only for types A and B.
- f6
-
Recommended for work involving direct contact with these agents.
- f7
-
Two viruses are identified: one a buffalopox type and the other a variant of the Vaccinia virus.
- f8
-
Variant of cowpox virus.
- f9
-
Variant of Vaccinia.
- f10
-
At present there is no evidence of disease in humans caused by the other retroviruses of simian origin. As a precaution containment level 3 is recommended for work with them.
- f11
-
Hepatitis delta virus is pathogenic in workers only in the presence of simultaneous or secondary infection caused by hepatitis B virus. Vaccination against hepatitis B virus will therefore protect workers who are not affected by hepatitis B virus against hepatitis delta virus.
Notes on Division BACTERIA
Footnotes
- f1
-
See paragraph 8 of the introductory notes.