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Division 1.5.7 Organ weights

United Kingdom

Original text. Later amendments are not shown.

At the time of termination, body weight and the weight of the following organs of all P and F1 parental animals shall be determined (paired organs should be weighed individually):

  • Uterus, ovaries;

  • Testes, epididymides (total and cauda);

  • Prostate;

  • Seminal vesicles with coagulating glands and their fluids and prostate (as one unit);

  • Brain, liver, kidneys, spleen, pituitary, thyroid and adrenal glands and known target organs.

Terminal body weights should be determined for F1 and F2 pups that are selected for necropsy. The following organs from the one randomly selected pup/sex/litter (see section 1.5.6) shall be weighed: Brain, spleen and thymus.

Gross necropsy and organ weight results should be assessed in context with observations made in other repeated dose studies, when feasible.