Division 2.7 Solubility in organic solventsF1

The solubility of the active substances as manufactured in the following organic solvents at 15 to 25 °C must be determined and reported if less than 250 g/kg; the temperature applied must be specified:

• Aliphatic hydrocarbon: preferably n-heptane,

• Aromatic hydrocarbon: preferably xylene,

• Halogenated hydrocarbon: preferably 1,2-dichlorethane,

• Alcohol: preferably methanol or isopropyl alcohol,

• Ketone: preferably acetone,

• Ester: preferably ethyl acetate.

If for a particular active substance, one or more of these solvents are unsuitable (e.g. reacts with test material), alternative solvents can be used instead. In such cases, the choices made must be justified in terms of their structure and polarity.