Division 2.6 Solubility in organic solvents

The solubility of the active substances as manufactured or purified active substance in the following organic solvents at 15 to 25 °C shall be determined and reported if less than 250 g/L; the temperature applied shall be specified. Results shall be reported as g/L.

1. (a)

   Aliphatic hydrocarbon: preferably heptane

2. (b)

   Aromatic hydrocarbon: preferably toluene

3. (c)

   Halogenated hydrocarbon: preferably dichloromethane

4. (d)

   Alcohol: preferably methanol or isopropyl alcohol

5. (e)

   Ketone: preferably acetone

6. (f)

   Ester: preferably ethyl acetate.

If for a particular active substance, one or more of those solvents is unsuitable (for example reacts with test material), alternative solvents may be used instead. In such cases, choices of solvents shall be justified in terms of their structure and polarity.